Injection through clothing should be avoided by all means, since fibers from the tissue or dirt could reach subcutaneous tissue. This could lead to painful infections that are completely preventable with hygienic injection. Another disadvantage is that the extreme sharp cut of the pen needle tip could be bent while going through the clothing and thus the injection will get painful.
The injection site should also be controlled for blood or insulin residues after each injection, which is not possible when injected through clothing.
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